Six Impactful Equine Research Projects Supported by The Foundation for the Horse

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The Foundation for the Horse has awarded $110,277 for six innovative equine research projects. These projects were conducted by AAEP-member graduate students, residents, or postdoctoral fellows. Over the last four years, The Foundation has provided $436,675 to support meaningful equine research by up-and-coming investigators. In this way, it continues to help pioneer medical advances in equine health.

“Scientific discovery and innovation bring the future of equine medicine into reality,” said Dr. Anthony Blikslager of The Foundation’s Research Review Group. “This Foundation is unrelentingly dedicated to the veterinary profession and to the horse’s health.”

For the third consecutive year, The Foundation joined the Thoroughbred Education and Research Foundation (TERF). This year TERF, whose mission is to make racing safer through research and education, increased its support by funding three important research projects with the potential to impact the health and safety of Thoroughbred athletes.

Projects Sponsored by The Foundation for the Horse

The supported research projects with researcher names and summaries follow:

Dual licensing of mesenchymal stem cells to enhance tendon healing (TERF sponsored)

Dr. Drew W. Koch, North Carolina State University 

Utilize in vitro co-culture assays to determine if IL-1b and/or TGF-b2 licensed mesenchymal stem cells (MSC) positively affect equine superficial digital flexor tendon tenocyte growth, function, and expression of tendon-relevant genes and proteins to support future in vivo studies examining licensed MSC therapy for equine tendon injury.

In vitro analysis of the optimization of stem cell therapy for the treatment of osteoarthritis using equine synovial fluid derived from mesenchymal stem cells with a soluble epoxide hydrolase inhibitor (TERF sponsored)

Dr. Alexandra Carlson, University of Tennessee

To determine if using soluble epoxide hydrolase inhibitors (sEHi) with stem cell therapy can improve stem cell activity by reducing inflammation in the joint while also eliminating adverse effects on the stem cells that typical anti-inflammatory treatment can have.

Clinical evaluation of a rapid test strip, PCR, and enriched-aerobic culture for the detection of salmonella enterica in equine feces

Dr. Emily Herring, University of Georgia

Evaluate the rapid test’s performance, compared to culture and PCR, for the detection of salmonella in equine fecal samples by performing all three tests in parallel on the same samples to assess their ability to determine whether a horse is infected with salmonella correctly.

Short-term oil dietary supplementation affects oocyte and cumulus cell metabolism in old mares

Dr. Giovana Di Donato Catandi, Colorado State University

Investigate how oils rich in omega-6 or omega-3 fatty acids affect the metabolic function of the oocyte and ovarian follicle cells and determine if additional dietary supplements can optimize fatty acid use in the ovarian follicle while reducing potential side effects.

A pilot study on an experimental model for Palmar Osteochondral Disease (POD) in horses (TERF sponsored)

Dr. Lauren Smanik, Colorado State University

To develop an experimental model of Palmar Osteochondral Disease (POD) that would allow researchers to study the progression in a controlled, prospective manner that will allow for future studies on variables that may affect lesion severity and facilitate the development of an optimized treatment plan. 

Investigation of MARCKS protein as a novel therapeutic target to decreased neutrophil extracellular traps (NETs) in equine asthma

Dr. Bethanie L. Cooper, North Carolina State University

To identify novel treatment alternatives to steroid therapy for horses with equine asthma through neutrophil extracellular traps, released by airway neutrophils, as potential therapeutic targets.

Application for The Foundation for the Horse 2023 Research Grant Program

Equine research is one of three pillars of impact—along with education and horses at risk—supported by The Foundation. The 2023 application window for this research grant program will open early next year. To learn more, visit https://www.foundationforthehorse.org/graduate-student-fellow-resident-research-grants/

About The Foundation for the Horse

Established in 1994, The Foundation for the Horse is a 501(c)(3) charitable organization dedicated to improving the welfare of the horse through Education, Research, and Horses at Risk. It is governed and stewarded by world-renowned equine veterinarians and equine stakeholders. In 2022, and for the second consecutive year, The Foundation awarded over $1 million in scholarships and grants to impact equine health and well-being throughout the U.S. and developing countries. To learn more, visit http://www.foundationforthehorse.org

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