Dynamic Testing for PPID in Donkeys

Spanish and US researchers evaluated dynamic testing for PPID in donkeys.

The TRH stimulation test is recommended as a dynamic test for the diagnosis of PPID in donkeys. Kimberly S. Brown

This prospective study by S. Mejia‐Pereira and colleagues in Spain and the USA aimed to evaluate dynamic testing for PPID in donkeys. This is an open-access study.

Six donkeys with clinical signs consistent with PPID and a basal adrenocorticotropic hormone (ACTH) concentration >50 pg/mL were included in the study. A dexamethasone suppression test (DST), thyrotropin‐releasing hormone (TRH) stimulation test and combined DST-TRH challenge were performed in all animals during the summer months with a 1‐week washout period between tests.

The TRH stimulation test identified all six donkeys as having PPID, whereas the DST and the DST-TRH identified 3/6 and 4/6 donkeys, respectively. Agreement between the DST and the DST-TRH tests was poor.

Bottom line: The TRH stimulation test is recommended as a dynamic test for the diagnosis of PPID in donkeys.

The authors of this study were Mejia‐Pereira, S.; Perez‐Ecija, A.; Buchanan, B.R.; Toribio, R.E.; and Mendoza, F.J.

This open access article can be accessed  on the Wiley online library

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