This prospective study by S. Mejia‐Pereira and colleagues in Spain and the USA aimed to evaluate dynamic testing for PPID in donkeys. This is an open-access study.
Six donkeys with clinical signs consistent with PPID and a basal adrenocorticotropic hormone (ACTH) concentration >50 pg/mL were included in the study. A dexamethasone suppression test (DST), thyrotropin‐releasing hormone (TRH) stimulation test and combined DST-TRH challenge were performed in all animals during the summer months with a 1‐week washout period between tests.
The TRH stimulation test identified all six donkeys as having PPID, whereas the DST and the DST-TRH identified 3/6 and 4/6 donkeys, respectively. Agreement between the DST and the DST-TRH tests was poor.
Bottom line: The TRH stimulation test is recommended as a dynamic test for the diagnosis of PPID in donkeys.
The authors of this study were Mejia‐Pereira, S.; Perez‐Ecija, A.; Buchanan, B.R.; Toribio, R.E.; and Mendoza, F.J.