EHV-1: Current Vaccines, Challenges, & Future Directions

Research on EHV-1 vaccination is ongoing, but scientists now have an option that could yield promising results for protection against EHM.
This article originally appeared in the Spring 2025 issue of EquiManagement. Sign up here for a FREE subscription to EquiManagement’s quarterly digital or print magazine and any special issues.
Horses at a horse show, where EHV-1 and EHM can potentially spread.
Researchers are trying to develop efficacious vaccines that protect beyond the respiratory form of EHV-1 to mitigate EHM. | Adobe Stock
Equine herpesvirus-1 (EHV-1) and equine herpesvirus myeloencephalopathy (EHM) have huge economic impacts on the equine industry besides expensive and tragic cases treating affected horses. When outbreaks occur, owners worry their horses might contract EHM, events get canceled, and quarantine measures must be implemented. About 10% of horses infected with EHV-1 develop neurologic disease from EHM. With this in mind, researchers are trying to develop vaccines that protect beyond the respiratory form to mitigate EHM and possibly abortion. Gisela Soboll Hussey, DVM, MS, PhD, Professor of Pathology and Diagnostics at the Michigan State College of Veterinary Medicine, recently discussed updated research in this vaccine field during a presentation at the University of Kentucky’s Gluck Equine Research Center.
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